By Philip R Reilly
Twenty-four real, wide-ranging stories of crime, heritage, human habit, disorder, and ethics, advised from the private viewpoint of the writer, an eminent physician-lawyer who makes use of the tales to demonstrate the rules of human genetics. Philip Reilly makes use of those tales to demonstrate the foundations of human genetics and to debate the wider matters.
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Extra resources for Abraham Lincoln’s DNA and Other Adventures in Genetics
In a span lasting less than 20 years and hampered by physical deformity and severe alcohol abuse, he produced 737 canvases, 275 watercolors, 368 prints and posters, and 5,084 drawings. Almost certainly, he created hundreds of other works that he destroyed or simply left behind in the brothels and dance halls of late 19th century Paris. As one turns the pages of an art book or strolls through the museum at Albi, it is hard to think of Toulouse-Lautrec as a man with a disability. Czar Nicholas II and his family.
The journal had a subscription list of only 120, and the paper elicited no known effort to replicate its findings, a critical process for all scientific discoveries, for nearly 35 years. Mendel himself published only one other paper on plant breeding. In 1869, he reported that working with a plant called hawkweed (Hieracium) he had been unable to demonstrate the particulate nature of the hereditary material that he had shown so convincingly in his study of garden peas (Pisum sativum). We have no idea why Mendel began his exhaustive study of heredity, but we do know why he chose garden peas.
Can we be sure that Toulouse-Lautrec suffered from pycnodysostosis? No. Could the diagnosis be made definitively or excluded? Yes. There are two possibilities. If descendants of his sister (who, assuming the diagnosis is correct, would have had a 2 in 3 chance of having inherited one copy of the allele) provided blood samples in which DNA analysis showed the 36 ■ H I STO RY presence of a copy of a mutated cathepsin K gene, it would by inference clinch the historical diagnosis. If descendants were to successfully petition a court for permission to exhume the artist’s remains, then DNA analysis of a bone fragment might provide a definitive answer.
Abraham Lincoln’s DNA and Other Adventures in Genetics by Philip R Reilly