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Download PDF by Richard M. Schultz: Advances in Targeted Cancer Therapy (Progress in Drug

By Richard M. Schultz

ISBN-10: 3764371749

ISBN-13: 9783764371746

ISBN-10: 3764374144

ISBN-13: 9783764374143

This quantity is the 1st ebook to hide the final subject of precise melanoma remedy. It provides more than a few pursuits resembling tumor angiogenesis, telephone cycle regulate and cellphone signalling, COX-2, apoptosis/cell survival, invasion and metastasis and methods like kinase inhibitors, antisense, and antibody-based therapeutics. The emphasis is on preclinical improvement, together with objective validation, improvement of biomarkers, techniques for mix ways, and improvement of resistance. the actual demanding situations concerned about translating those facts to medical program are mentioned. This quantity might be of wide basic curiosity to researchers and clinicians interested in melanoma remedy in addition to different scientists drawn to present techniques for melanoma remedy.

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Additional info for Advances in Targeted Cancer Therapy (Progress in Drug Research)

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HER-2 is amplified and overexpressed in 25–30% of human breast cancers [10–13]. In NIH-3T3 cells and immortalized human breast cells, overexpression of the HER-2 gene produces a neoplastic transformation [13–17]. Pegram et al. [18] found that transfecting human breast and ovarian cancer cell lines with HER-2/neu did not significantly alter their response to a variety of chemotherapeutic agents in cell culture, or when grown as xenograft tumors. However, when human breast and ovarian cell lines that overexpress HER-2 were grown as xenografts in nude mice, their growth was inhibited by administration of a recombinant humanzied monoclonal antibody to HER-2 [19, 20].

Anticancer Res 23: 1159–1161 Davis DW, McConkey DJ, Abbruzzese JL, Herbst RS (2003) Surrogate markers in antiangiogenesis clinical trials. Br J Cancer 89: 8–14 Korn EL, Arbuck SG, Pluda JM, Simon R, Kaplan RS, Christian MC (2000) Clinical trial designs for cytostatic agents: are new approaches needed? J Clin Oncol 19: 265–272 Rinehart J, Adjei AA, LoRusso PM, Waterhouse D, Hecht JR, Natale RB, Hamid O, Varterasian M, Asbury P, Kaldjian EP et al (2004) Multicenter Phase II study of the oral MEK inhibitor, CI-1040 in patients with advanced non-small cell lung, breast, colon and pancreatic cancer.

In a number of cases, these agents lead to brisk tumor shrinkage in preclinical systems. It is fair to say that there are very few truly cytostatic agents in clinical development at the present time. The demonstration of rapid achievement of tumor dormancy using FGDPET imaging in gastrointestinal stromal tumors (GISTs) that antedate subsequent tumor size reduction with conventional imaging modalities such as CT scan and MRI [22] holds promise for functional imaging as a future tool that may be explored.

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Advances in Targeted Cancer Therapy (Progress in Drug Research) by Richard M. Schultz

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