By F. S. Philips (auth.), Franco M. Muggia, Charles W. Young, Stephen K. Carter (eds.)
F. M. MUGGIA while confronted with the inadequacies of present melanoma remedy, we wish to examine what the long run may perhaps carry. commonly, we take without any consideration the previous, who prefer study into completely new parts. in spite of the fact that, the chronic improvement of fertile soil might yield striking rewards in case you decide to construct at the wisdom of the past--hence, this symposium on anthracycline antibiotics. even supposing the anthracycline antibiotics signify a lot of the current and way forward for melanoma therapy, their real use c stretches again slightly 20 years to the pioneering efforts of Aurelio Di Marco, who characterised the antitumor homes of daunomycin and adriamycin. * The medical software of those compounds heralded a decade of pleasure between oncologists facing pediatric tumors, breast melanoma, leukemias, and lymphomas, and opened new desire for sufferers troubled with sar comas and a number of different tumors that have been deemed - sistant to chemotherapy. those successes have been tempered with the belief that the antitumor impression of anthracyclines might be accomplished from time to time merely on the very excessive cost of risking cardiac decompensation and, virtually consistently, with the prevalence of alopecia and different acute toxicities. This checklist of earlier achievements and difficulties has slowly given technique to a gift more and more illuminated by way of our skill to change the distressing toxicities of those brokers. designated medical experiences supplemented by means of creative laboratory types have progressively elucidated mechanisms and threat elements im plicated within the cardiomyopathy.
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Extra resources for Anthracycline Antibiotics in Cancer Therapy: Proceedings of the International Symposium on Anthracycline Antibiotics in Cancer Therapy, New York, New York, 16–18 September 1981
0. 5 in C3H mice. (d) % regression of tumor volume. D. 25 in C3H mice. Table 7 reports the data obtained against human mammary carcinomas transplanted into nude mice (57), and against the spontaneous mammary carcinoma of C3H female mice at its 3rd transplant. These tumors are highly sensitive to the OX activity, in good correlation with the clinical data. 4'-OeoxyOX also shows a very good antitumor activity, but some tumors seem less sensitive to 4'-deoxyDX than to OX. 24 Table 8. Effects of OX and 4'-deoxyOX against colon carcinomas Compound T 183 DX c 4'-deoxyDX e 19 65 % inhibitiona Human 5 T 219 T 374 T 380 Mouse 26 38 63 d >99 52 67 44 72 33 59 67 90 (a) See Table 2.
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In Mihich E, ed. Drug resistance and selectivity. Biochemicaland cellular basis. New York, Academic Press, pp. 1-40. Schwartz HS, r1ihich E. 1973. Species and tissue differences in drug selectivity. In Mihich E, ed. Drug resistance Emd selectivity. Biochemical and cellular basis. New York, Academic Press, pp. 413-452. Sirotnak FM, Chello PL, Degraw JI, Piper JR, M:mtgomery JA. 1981. Membrane transport and the molecular basis for selective antitumor action of folate analogs. , Lazo JS, Bertino JR, eds.
Anthracycline Antibiotics in Cancer Therapy: Proceedings of the International Symposium on Anthracycline Antibiotics in Cancer Therapy, New York, New York, 16–18 September 1981 by F. S. Philips (auth.), Franco M. Muggia, Charles W. Young, Stephen K. Carter (eds.)