By Itzhak Ofek
Attachment to host cells or tissues is frequently step one within the institution of bacterial infections. a fancy array of popularity, attachment, and virulence elements is fascinated by this approach, which fresh study has drastically illuminated. This entire and authoritative quantity discusses the categorical mobilephone and tissue-specific affinities of pathogenic microorganisms, together with bioinorganic surfaces reminiscent of tooth, and is a vital reference for researchers and scholars of host-pathogen interactions.
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Extra resources for Bacterial Adhesion to Cells and Tissues
These qualities can be modulated by pH, composition and physical state of growth medium, and presence of sublethal concentrations of antibiotics. The variables may either affect the functional expression of the adhesin or alter the bacterial surface to express an alternative mechanism of adhesion. These variables can be identified and manipulated in vitro, but it can only be assumed that similar kinds of changes in adhesive properties are elicited under natural conditions. The natural target surface also is probably dynamic, constantly changing with each new condition it faces.
Microbiol. 49:1351-1355. , CG. J. Fenver. 1985. Characteristics of the adherence of oral Hemophilius species to an experimental salivary pellicle and to other oral bacteria, In: Mergenhagen, S. and B. ), Molecular Basis of Oral Microbial Adhesion. American Society for Microbiology, Washington, pp. 94-102. M. Switalski, A. Lundin, G. Pulverer, and T. Wadstrom. 1985. Bioluminescent assay for measurement of bacterial attachment to polyethylene. J. Microbiol. Methods 4:169-177. A. and M. Marling-Cason.
Receptors for bacterial adhesins are probably no exception. Unfortunately, factors that govern the presentation and distribution of receptors that bind bacteria have not been studied in depth. Characterization of Cell Surface Receptors Identification and characterization of a cell surface constituent as a receptor for a biological agent requires (1) characterization of the nature of the attachment site(s); (2) isolation of the receptor molecule that contains the attachment site(s) from the cell membrane and its subsequent physicochemical characterization; (3) demonstration that it is available to the agent on the cell surface; and (4) proof that it mediates the biological activity of the agent.
Bacterial Adhesion to Cells and Tissues by Itzhak Ofek