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Download e-book for iPad: Biosynthetic Products for Cancer Chemotherapy: Volume 1 by George Pettit

By George Pettit

ISBN-10: 1468472305

ISBN-13: 9781468472301

ISBN-10: 1468472321

ISBN-13: 9781468472325

Cancer exacts an exceptionally damaging toll at the world's human populations. in recent times we have now often heard the expression "war on cancer," yet in comparison to the carnage inflicted via melanoma, our clinical and scientific efforts, thus far, would appear extra like a minor skirmish. a few comprehension of the melanoma challenge could be got from a glance on the present and projected casualty checklist for the USA. during this state, approximately 700,000 new instances of melanoma can be clinically determined in 1976 and over 1 million recognized situations will remain taken care of. Over 400,000 of those sufferers will die from melanoma in our bicentennial 12 months. With the occurrence of melanoma within the usa expanding to 5.2% in 1975, in comparison to the 1.1 % every year expense skilled for many years, Dr. F. J. Rauscher, Jr.,338 Director of the nationwide melanoma Institute, has anticipated that greater than 10 million humans should be less than therapy for melanoma and approximately four million will expire from melanoma during this decade. At that fee, melanoma will seem in approximately of 3 households and the required treatment will rate a few $15-20 billion consistent with 12 months. hence until equipment for the remedy and regulate of melanoma are markedly greater, approximately fifty three million americans now alive will finally be melanoma sufferers. Unfor­ tunately the most important forms of human melanoma are nonetheless past healing care by way of surgical and radiological recommendations and thanks to the paucity of at the moment on hand melanoma chemotherapeutic medicinal drugs with healing potential.

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Q ;:! =- i ;;- (37) Testosterone propionate (38) Testosterone enanthate (36) Testolactone (Teslac) (35) Prednisone Drug Table 1-continued 600-1200 mg/wk, 1M 50-100 mg, 1M 3x/wk 100 mg 3x/wk, 1M 10-100 mg/day PO Usual dosage None None None None Acute Delayed Fluid retention, masculinization Fluid retention, masculinization Fluid retention, masculinization Hyperadrenocorticism Toxicity Breast carcinoma Breast carcinoma Acute and chronic lymphocytic leukemia, Hodgkin's disease, non-Hodgkin's lymphomas Breast carcinoma Major indications ....

440 Podophyllum peltatum L. (Berberidaceae) is another plant with a long history of use in primitive medicine and was already under investigation in the 1940's by Hartwell at the National Cancer Institute. 143 These pioneering studies led to 50 Chapter 2 recognition of the cytotoxic properties of podophyllotoxin and more recently to preparation of 4' -demethylepipodophyllotoxin-I3-D-thienylidene-glucoside (94) of current interest, for example, in treatment of intracranial neoplasms. 93 ,281,374 By 1958, the characterization and application of the Vinca rosea alkaloids vinblastine (105)72,73,74,282 and vincristine (104)277,386 were already well under way.

79 ,81 As he noted, a single-drug treatment would be an ideal method of cancer treatment, but several such drugs in combination are now known to give improved responses and survival rates. The whole concept of combination drug treatment for cancer seems most attractive and logical, as this would allow more chemical pathways to be interrupted simultaneously with less possibility of the emergence of a drug-resistant tumor line. 443 The four-drug treatments for acute lymphocytic leukemia and Hodgkin's disease are fine illustrations of this point.

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Biosynthetic Products for Cancer Chemotherapy: Volume 1 by George Pettit

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