By Israel Penn (auth.), J. L. Touraine, J. Traeger, H. Bétuel, J. M. Dubernard, J. P. Revillard, C. Dupuy (eds.)
Malignancies are widespread problems in organ transplantation, frequently because the results of an infection with yes viruses and of long term immunosuppression. The epidemiology confirms that the elevated occurrence issues yes cancers, in particular HIV-related pores and skin cancers and EBV-related lymphoproliferative malignancies.
This ebook covers all presently on hand details in this very important subject of the relationships among transplantation and malignancies: preexisting cancers, posttransplant cancers, their etiology and pathophysiology, their prevention and remedy. an important a part of the amount is dedicated to prophylaxis, early detection and smooth kinds of remedy in posttransplant lymphomas. As a end of these kind of new info, the idea of immunosurveillance merits to be considerably modified.
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Extra resources for Cancer in Transplantation: Prevention and Treatment: Proceedings of the 27th Conference on Transplantation and Clinical Immunology, 22–24 May 1995
Seventeen patients received a cadaveric renal transplant 0 to 150 months after tumor diagnosis (median = 73 months) and 9 to 128 months after dialysis initiation (median = 55 months). Induction immunosuppressive regimen included anti-thymocyte globulines  or monoclonal antibodies  in 16 out of 17 cases. Cyclosporine A was used as maintenance therapy in 13 cases (in combination with azathioprine and prednisone in 7 cases, azathioprine in 3 cases, and prednisone in 3 cases). Seven recipients experienced no rejection episodes, while 5 experienced 1 and 5 experienced 2 or more.
He found 34 donors with primary brain tumor supplying 84 organs upon more than 2000 donors. 74% of tumors were glial tumors and the majority of them were ofa high grade malignancy. From this group, malignancies developed in 2 renal allograft recipients leaving an overall incidence of transmission from a donor with malignant cerebral histology of 3%. In adults, about 40% of primary brain tumors and glioblastomas represent approximately 50% of all gliomas (10). Glioblastoma multi forme is histologically, with medulloblastoma, the most malignant of glial tumors.
The analysis was based on transplants reported to the Collaborative Transplant Study . To eliminate the problem of "underreporting", all participating centers were asked to provide written confirmation that the posttransplant information on malignant tumors was accurate and complete. Only data from those centers who provided this verification were included in the analysis. Positive verification was received from 282 kidney transplant centers, 105 heart transplant centers and 40 liver transplant centers.
Cancer in Transplantation: Prevention and Treatment: Proceedings of the 27th Conference on Transplantation and Clinical Immunology, 22–24 May 1995 by Israel Penn (auth.), J. L. Touraine, J. Traeger, H. Bétuel, J. M. Dubernard, J. P. Revillard, C. Dupuy (eds.)