By E. V. Sugarbaker, D. N. Seckinger, O. O. Frankfurt (auth.), Prof. Dr. Volker Schirrmacher, Dr. Reinhard Schwartz-Albiez (eds.)
These are the complaints of the 2d overseas Metastasis Congress of the Metastasis learn Society which came about within the city corridor (Stadthalle) of Heidelberg, FRG, in September, 1988. this primary Metastasis Congress within the FRG used to be prepared at the side of the German organization of melanoma study (SEK) of the German melanoma Society. The congress subject generated large curiosity and attracted approximately four hundred scientists from 22 international locations. such a lot members got here from Europe, Israel, and the us. Why did we set up the Metastasis Congress? purely approximately 50% of every person who improve a few kind of melanoma are curable. regardless of superior sufferer care and more and more leading edge and powerful concepts for diagnosing and treating basic cancers, the advance of secondary melanoma colonies, i. e. , metastasis, can't be avoided and is the key reason for demise. within the Federal Republic of Germany there are nonetheless as many as a hundred and sixty 000 melanoma sufferers according to 12 months who succumb to their affliction, usually after classes of bad agony, and this total determine isn't bettering. partially as a result of the complexity of the method, uncomplicated examine on metastasis has lagged in the back of different disciplines akin to carcino genesis and melanoma genetics. Metastasis formation consists of the facility of malig nant cells to invade adjoining tissue and to penetrate into lymphatic or blood circulatory structures, or either, and to unfold to close or far-off websites to shape new tumor colonies. in the meantime, study on metastasis is receiving a lot attention.
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Additional info for Cancer Metastasis: Molecular and Cellular Biology, Host Immune Responses and Perspective for Treatment
V. injection in syngeneic mice, in contrast to the BW5147 parental cell line (Roos et al. 1985). Based on the results obtained with the intraspecies mouse T cell hybrids, we hypothesized that normal human-activated T lymphocytes or human leukemia T cells, or both, might contain active genes responsible for invasiveness. To demonstrate the existence of such a gene (or genes) and to reveal their chromosomal localization, interspecies human-mouse T cell hybrids were generated by fusion of BW5147 mouse cells with either phytohemagglutinin (PHA)-stimulated normal human T lymphocytes or human acute lymphoblastic leukemic T cells.
1987b). g/ml 5-azaC yielded invasive subpopulations of cells after five selection rounds. Subclones of these cultures showed different invasive potential (Table 1) and were further analyzed. Five highly invasive clones were cultured for prolonged time (up to 3 months) and showed stable expression of the invasive phenotype. Preliminary results indicate that these invasive cells also produce metastases after tail-vein injection in syngeneic AKR mice. These data indicate that 5-azaC is able to induce invasive potential in the BW5147 T lymphoma cells, presumably by demethylation and thus activation of one or more silent genes.
1987). v. injected cells in the lungs is by no means as fast as often supposed; b) malignant conversion in vivo does occur. The question therefore remains whether the ras oncogene product confers de novo malignancy on the recipient cells or merely speeds up their intrinsic tendency of progression by, for instance, promoting ectopic growth. ; see below) after ras-oncogene transfection might favor the former theory. In contrast, increased growth potential and autonomy of ras-transfectants has been described several times as well (see below also).
Cancer Metastasis: Molecular and Cellular Biology, Host Immune Responses and Perspective for Treatment by E. V. Sugarbaker, D. N. Seckinger, O. O. Frankfurt (auth.), Prof. Dr. Volker Schirrmacher, Dr. Reinhard Schwartz-Albiez (eds.)