By Thomas Arendt (auth.), Agata Copani M.D., Ph.D., Ferdinando Nicoletti M.D. (eds.)
Cell-Cycle Mechanisms and Neuronal phone demise examines the function of cellphone cycle activation within the molecular mechanisms resulting in neuronal degeneration. best Authors speak about this subject relating to the most important neurological problems, together with Alzheimer’s ailment, stroke and epilepsy. This publication serves to achieve new insights into the molecular determinants of neuronal dying and to set up new objectives for healing intervention.
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Extra resources for Cell-Cycle Mechanisms and Neuronal Cell Death
Using pharmacological approaches, the laboratories of Greene and colleagues have shown that drugs block cell cycle advancement are efficient at preventing the death of both PC 12 cells and sympathetic neurons. ^^'^^ Molecular genetic approaches have also been used. Dominant negative forms of the Cdk4 and Cdk6 proteins have been engineered and these too are effective in blocking the cell death process. ^^ These in vitro models are significant since many of them provide direct experimental evidence that, rather than merely being associated with cell death, an ectopic cell division is both necessary and sufficient to produce the death of neurons.
46. Kim L, Kimmel AR. GSK3, a master switch regulating cell-fate specification and tumorigenesis. Curr Opin Genet Dev 2000; 10:508-514. A7. Morin PJ. p-catenin signaling and cancer. BioEssays 1999; 21:1021-1030 48.
Using a battery of cell cycle protein antibodies, we found that in both hippocampus and basal nucleus there is a significant percentage of cell cycle immunopositive neurons in all MCI cases (Fig. IC, D). Indeed, the percentages turn out to be very similar to those found in Alzheimer's disease cases, and significantly higher than in cognitively intact controls. This means that cell cycle-related cell death is not a peculiarity of late stage disease and suggests that it represents a unifying disease mechanism.
Cell-Cycle Mechanisms and Neuronal Cell Death by Thomas Arendt (auth.), Agata Copani M.D., Ph.D., Ferdinando Nicoletti M.D. (eds.)