By Michael F. Holick (auth.), Dr. Jörg Reichrath, Prof.Dr. Wolfgang Tilgen, Dr. Michael Friedrich (eds.)
ISBN-13: 9783642624353This quantity presents a accomplished, hugely readable review of the subjects mentioned on the First foreign Symposium on "Vitamin D Analogs in melanoma Prevention and remedy" held in Homburg/Saar, Germany in could 2002. best researchers talk about our current wisdom of the nutrition D procedure in melanoma. subject matters diversity from the most recent findings in molecular biology, epidemiology, synthesis and metabolism of diet D to new suggestions for using nutrition D analogs in melanoma prophylaxis and therapy. The booklet offers crucial updated info for each researcher or clinician drawn to the biology of nutrition D or cancer.
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Extra resources for Vitamin D Analogs in Cancer Prevention and Therapy
Due to its bulky side chain, which causes steric hindrance to helix 12, an antagonist such as ZK168281 can never convert to a superagonist. In contrast, the nonagonist Gemini turns into an agonist or even a superagonist, when VDR is exposed to lower CoR levels, binds as a heterodimer with RXR to DNA, and is contacted by CoAs (Herdick et al. 2000a). Therefore, Gemini seems to be able to discriminate between the 40 Carsten Carlberg well-characterized signaling via DNA-bound VDR-RXR heterodimers and less well-understood DNA-independent regulatory actions of the VDR.
Smoking may be a weak risk factor (Khuder et al. 2001), while one study has found that consumption of alcohol is associated with a linear increase in breast cancer incidence (Smith-Warner et al. 1998). As already stated, hereditary breast cancers account for only around 5%– 10% of cases. Therefore the vast majority of breast tumours are sporadic and the underlying causes are poorly understood, but may be affected by some of the factors outlined above. In addition, it has been postulated that predisposi- Approaches to Evaluating the Association of Vitamin D Receptor Gene Polymorphisms 45 tion to breast cancer could be attributable to multiple, common but individually weak genes (reviewed in de Jong et al.
For the ER, the term “selective ER modulator” (SERM) has been applied to compounds with mixed agonist and antagonist activity such as tamoxifen and raloxifene (McDonnell 1999). Therefore, ZK159222 and TEI-9647 also could be referred to as selective VDR modulators. Molecular dynamics simulations of VDRs LBD complexed with the natural agonist in comparison to ZK159222 and ZK168281 demonstrated that the extended side chain of both antagonists prevents the interaction between residues H397 and F422 (Väisänen et al.
Vitamin D Analogs in Cancer Prevention and Therapy by Michael F. Holick (auth.), Dr. Jörg Reichrath, Prof.Dr. Wolfgang Tilgen, Dr. Michael Friedrich (eds.)